Endocrine Abstracts

Obesity and type 2 diabetes are expanding rapidly and become a wide world health issue. These metabolic diseases are tightly associated with an insulin resistance state. Among insulin target tissues, liver plays a central role in the regulation of glucose homeostasis.Insulin action is initiated by its binding to its receptors (IR) which, once activated, phosphorylate intracellular substrates and lead to the activation of transduction pathways implicating...

Grb14 is a molecular adaptor that inhibits insulin signaling by interacting with the activated insulin receptor and inhibiting its tyrosine kinase activity. In various models of insulin resistance, including obese mice and type 2 diabetes patients, an inverse correlation was reported between Grb14 expression in adipose tissue and insulin sensitivity. To elucidate Grb14 function in this specific tissue, we studied the impact of modifications of Grb14 level of expression on adip...